A Device for Shooting Drugs Straight to the Brain

Did you know that it is easier for an opioid to get to the brain than a drug designed to fight dementia?

This is because the drugs required to treat ailments such as brain tumors, dementia, Alzheimer’s and Parkinson’s disease have large molecules.

What is the difference between drugs with Large Molecules and those with Small Molecules?

Drugs with small molecules are lipophilic (a.k.a fat soluble) this makes it very easy for them to pass the blood-brain barrier (BBB). Drugs like morphine, aspirin, caffeine, opioids are all lipophilic drugs.

Drugs with large molecules on the other hand are usually protein-based drugs which are also hydrophilic (water soluable). Since the BBB is made up of endothelial cells which has a lipid membrane, it tends to repel most hydrophilic substances.

In simple terms

This is why CraniUS^™ Therapeutics works night and day to ensure they put an end to that.

Through their flagship product called NeuroPASS™.

What is NeuroPASS™?

NeuroPASS™ is a a fully implantable and rechargeable device designed to deliver medication directly to the brain.

NeuroPASS™ is still in its development stage so it is neither FDA cleared nor ready for purchase. However, it would begin the process of getting it in 2025.

Nevertheless, imagine the possibilites of having a tool like NeuroPASS™. This means that drugs needed to treat brain diseases be administered properly and save lives.

Types of Drugs NeuroPASS™ would be used deliver to the brain

Large Molecule Drugs:

Biologic therapies such as monoclonal antibodies (e.g., rituximab, trastuzumab) which are used for conditions like cancer or autoimmune disorders (dementia and Parkinsons disease).

Most Chemotherapy Drugs:

Drugs like cisplatin and methotrexate would be adminstered straight to the brain to treat brain tumors and cancers that affect the brain.

What the experts are saying

Now that you’ve read all about the CraniUS NeuroPass, what do you think? Let us know in the comments. We would love to read your thoughts.

Until next time.